Atletico Madrid striker Radamel Falcao has been named in the Premier League’s squad for the final four games of the season.
However, the midfielder has not been included in the starting line-up since a hamstring injury against Chelsea.
It is a blow for Southampton, who have a home tie against Watford on Sunday before a return trip to Liverpool on March 18.
Falcao missed the Champions League group stages with an ankle injury, but the club said the injury was a result of a pre-season conditioning drill and he has recovered fully.
His absence means the Saints have been forced to rely on their young players, with the likes of Tom Carroll, Danny Rose and Benik Afobe also sidelined.
With all the uncertainty surrounding the club, Southampton manager Ronald Koeman is keen to bolster his squad.
He said: “We will try to get something good for the last four games.
If we are in a good place then I think we can be in a top four.”
I’m not in a position where I can say that we are not going to be very competitive and that is the big thing, is that we want to be in the top four.
“That is the aim.”
Southampton’s first match in eight days is against Swansea City, but Koeman said he would not rule out a return to action against Arsenal.
He added: “If we are playing well, then we can play again.”
But if we are doing well, we need to wait and see.